On the other side, Davis Mills (filling in again for the injured C.J. Stroud) won't face as difficult a unit in the Bills defense. Sean McDermott's defense has given up at least 30 points in back-to-back games and has one of the worst run defenses in the NFL, allowing teams to average 153 yards per game on the ground (31st).

Steelers at Bears (-2.5): Aaron Rodgers has a broken left wrist, and may or may not play. If he can't go, the Steelers will start Mason Rudolph, who is apparently still in the NFL. If Rodgers plays, that injury is going to affect him, even if it's not on his throwing arm.

Which NFL teams have the best chances of winning their games on the NFL Week 12 schedule? ESPN Analytics has revealed its Matchup Predictor numbers for the 14 games in the league this week, and they offer some interesting win probabilities. How correct ...

Check out our NFL Week 12 picks for the 14 NFL games this week, a week that begins with the Buffalo Bills at Houston Texans on Thursday Night Football on Nov. 20 and ends with the Carolina Panthers at San Francisco 49ers on Monday Night Football on Nov. 24.

As we noted in our overall staff picks earlier this week, recent history suggests the Lions are a very solid bet to win and cover this week. To revisit: The Lions are coming off a Week 11 loss to the Eagles,

Week 14 of the NFL season is the last time that we'll have bye weeks in play during the regular season, but there are still 14 great games to bet on this week,

Which NFC North wide receivers show out? Will Myles Garrett break the single-season sack record on Sunday? Our analysts provide bold predictions for Week 14 of the 2025 NFL season.

According to the SportsLine Inside the Lines team's projection model, the outcome of Sunday's Bears vs. Packers matchup could play a major role in who wins the division title