Lore never changes.

Fallout 5 will indeed take into account the canon events of the Fallout TV series, Bethesda development chief Todd Howard has ...
IGN India

Fallout 5 Will Exist in a World Where 'The Stories and Events of the Show Happened or Are Happening,' Todd Howard Confirms

Fallout 5 will indeed take into account the canon events of the Fallout TV series, Bethesda development chief Todd Howard has ...